Adjusting for age improves identification of gut microbiome alterations in multiple diseases

TS Ghosh, M Das, IB Jeffery, PW O'Toole - elife, 2020 - elifesciences.org
Interaction between disease-microbiome associations and ageing has not been explored in
detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome …

Oral nanomedicine: challenges and opportunities

B Deng, S Liu, Y Wang, B Ali, N Kong, T Xie… - Advanced …, 2024 - Wiley Online Library
Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …

Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures

I Sobhani, E Bergsten, S Couffin… - Proceedings of the …, 2019 - National Acad Sciences
Sporadic colorectal cancer (CRC) is a result of complex interactions between the host and
its environment. Environmental stressors act by causing host cell DNA alterations implicated …

Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

F Beghini, LJ McIver, A Blanco-Míguez, L Dubois… - elife, 2021 - elifesciences.org
Culture-independent analyses of microbial communities have progressed dramatically in the
last decade, particularly due to advances in methods for biological profiling via shotgun …

Fusobacterium nucleatum secretes amyloid‐like FadA to enhance pathogenicity

Q Meng, Q Gao, S Mehrazarin… - EMBO …, 2021 - embopress.org
Fusobacterium nucleatum (Fn) is a Gram‐negative oral commensal, prevalent in various
human diseases. It is unknown how this common commensal converts to a rampant …

Strain-level epidemiology of microbial communities and the human microbiome

Y Yan, LH Nguyen, EA Franzosa, C Huttenhower - Genome medicine, 2020 - Springer
The biological importance and varied metabolic capabilities of specific microbial strains
have long been established in the scientific community. Strains have, in the past, been …

Gut microbiota in colorectal cancer: biological role and therapeutic opportunities

H Pandey, DWT Tang, SH Wong, D Lal - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

Meta-analysis of altered gut microbiota reveals microbial and metabolic biomarkers for colorectal cancer

N Avuthu, C Guda - Microbiology Spectrum, 2022 - Am Soc Microbiol
Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide. The
dysbiotic gut microbiota and its metabolite secretions play a significant role in CRC …

Diversity and distribution of sulfur metabolic genes in the human gut microbiome and their association with colorectal cancer

PG Wolf, ES Cowley, A Breister, S Matatov, L Lucio… - Microbiome, 2022 - Springer
Background Recent evidence implicates microbial sulfidogenesis as a potential trigger of
colorectal cancer (CRC), highlighting the need for comprehensive knowledge of sulfur …

A framework for effective application of machine learning to microbiome-based classification problems

BD Topçuoğlu, NA Lesniak, MT Ruffin IV, J Wiens… - MBio, 2020 - Am Soc Microbiol
Machine learning (ML) modeling of the human microbiome has the potential to identify
microbial biomarkers and aid in the diagnosis of many diseases such as inflammatory bowel …