The role of PGE2 and EP receptors on lung's immune and structural cells; possibilities for future asthma therapy

D Cebulla, C Van Geffen, S Kolahian - Pharmacology & Therapeutics, 2023 - Elsevier
Asthma is the most common airway chronic disease with treatments aimed mainly to control
the symptoms. Adrenergic receptor agonists, corticosteroids and anti-leukotrienes have …

[HTML][HTML] Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

C van Geffen, C Heiss, A Deißler… - Frontiers in …, 2022 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent
suppressive and regulative properties. MDSCs' strong immunosuppressive potential creates …

[HTML][HTML] Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine

F Wu, X Li, M Looso, H Liu, D Ding, S Günther… - Nature Genetics, 2023 - nature.com
Generation of functional transcripts requires transcriptional initiation at regular start sites,
avoiding production of aberrant and potentially hazardous aberrant RNAs. The mechanisms …

Multienzyme‐Like Nanozyme Encapsulated Ocular Microneedles for Keratitis Treatment

S Liu, Q Bai, Y Jiang, Y Gao, Z Chen, L Shang… - Small, 2023 - Wiley Online Library
Keratitis, an inflammation of the cornea caused by bacterial or fungal infections, is one of the
leading causes of severe visual disability and blindness. Keratitis treatment requires both …

[HTML][HTML] Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge

AL Voskamp, T Tak, ML Gerdes, R Menafra… - Journal of Experimental …, 2023 - rupress.org
Innate mononuclear phagocytic system (MPS) cells preserve mucosal immune homeostasis.
We investigated their role at nasal mucosa following allergen challenge with house dust …

ROS-scavenging glyco-nanoplatform for synergistic antibacterial and wound-healing therapy of bacterial keratitis

Y Zhang, G Li, X Zhang, L Lin - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Infectious keratitis is a serious disease originating when corneal trauma is infected with
bacteria and has difficulties in healing due to stubborn infection and persistent inflammation …

[HTML][HTML] Immune Metabolism in TH2 Responses: New Opportunities to Improve Allergy Treatment—Cell Type-Specific Findings (Part 2)

YJ Lin, A Goretzki, H Rainer, J Zimmermann… - Current Allergy and …, 2023 - Springer
Abstract Purpose of Review Over the last years, we have learned that the metabolic
phenotype of immune cells is closely connected to the cell's effector function. Understanding …

[HTML][HTML] Blockade of prostaglandin E2 receptor 4 ameliorates peritoneal dialysis-associated peritoneal fibrosis

Q Luo, M Liu, Y Tan, J Chen, W Zhang… - Frontiers in …, 2022 - frontiersin.org
Inflammatory responses in the peritoneum contribute to peritoneal dialysis (PD)-associated
peritoneal fibrosis. Results of our previous study showed that increased microsomal …

[HTML][HTML] Immune Metabolism–An Opportunity to Better Understand Allergic Pathology and Improve Treatment of Allergic Diseases?

A Goretzki, J Zimmermann, YJ Lin, S Schülke - Frontiers in Allergy, 2022 - frontiersin.org
Metabolism is defined as “the sum of the chemical reactions that take place within each cell
of a living organism and that provide energy for vital processes and for synthesizing new …

[HTML][HTML] EP2 and EP4 blockade prevents tumor-induced suppressive features in human monocytic myeloid-derived suppressor cells

J Cuenca-Escalona, B Subtil, A Garcia-Perez… - Frontiers in …, 2024 - frontiersin.org
Tumors educate their environment to prime the occurrence of suppressive cell subsets,
which enable tumor evasion and favors tumor progression. Among these, there are the …