Although single-cell and spatial sequencing methods enable simultaneous measurement of
more than one biological modality, no technology can capture all modalities within the same …

Our understanding of how global changes in cellular metabolism contribute to human kidney
disease remains incompletely understood. Here we show that nicotinamide adenine …

Kidney disease is a major driver of mortality among patients with diabetes and diabetic
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …

The ability to localize hundreds of macromolecules to discrete locations, structures and cell
types in a tissue is a powerful approach to understand the cellular and spatial organization …

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

Existing methods for analysis of spatial transcriptomic data focus on delineating the global
gene expression variations of cell types across the tissue, rather than local gene expression …

A large-scale multimodal atlas that includes major kidney regions is lacking. Here, we
employed simultaneous high-throughput single-cell ATAC/RNA sequencing (SHARE-seq) …

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. As many
genes associate with DKD, multi-omics approaches were employed to narrow the list of …

Renal fibrosis is the final stage of most progressive kidney diseases. Chronic kidney disease
(CKD) is associated with high comorbidity and mortality. Thus, preventing fibrosis and …

Acute kidney injury (AKI) is a common finding in hospitalized patients, particularly those who
are critically ill. The development of AKI is associated with several adverse outcomes …