Blood‐brain barrier overview: structural and functional correlation

A Alahmari - Neural plasticity, 2021 - Wiley Online Library
The blood‐brain barrier (BBB) is a semipermeable and extremely selective system in the
central nervous system of most vertebrates, that separates blood from the brain's …

[HTML][HTML] CAR T cell-based immunotherapy for the treatment of glioblastoma

L Maggs, G Cattaneo, AE Dal… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in adults. Current treatment options typically consist of surgery followed by …

Reviewing the significance of blood–brain barrier disruption in multiple sclerosis pathology and treatment

R Balasa, L Barcutean, O Mosora, D Manu - International journal of …, 2021 - mdpi.com
The disruption of blood–brain barrier (BBB) for multiple sclerosis (MS) pathogenesis has a
double effect: early on during the onset of the immune attack and later for the CNS self …

Neuroinflammation: the role and consequences

M Lyman, DG Lloyd, X Ji, MP Vizcaychipi, D Ma - Neuroscience research, 2014 - Elsevier
Neuroinflammation is central to the common pathology of several acute and chronic brain
diseases. This review examines the consequences of excessive and prolonged …

Targeting neuroinflammation in Alzheimer's disease

MR Bronzuoli, A Iacomino, L Steardo… - Journal of inflammation …, 2016 - Taylor & Francis
Almost 47 million people suffer from dementia worldwide, with an estimated new case
diagnosed every 3.2 seconds. Alzheimer's disease (AD) accounts for approximately 60 …

Inflammatory cell trafficking across the blood–brain barrier: chemokine regulation and in vitro models

Y Takeshita, RM Ransohoff - Immunological reviews, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is the brain‐specific capillary barrier that is critical for
preventing toxic substances from entering the central nervous system (CNS). In contrast to …

T‐cell trafficking in the central nervous system

F Sallusto, D Impellizzieri, C Basso… - Immunological …, 2012 - Wiley Online Library
To perform their distinct effector functions, pathogen‐specific T cells have to migrate to target
tissue where they recognize antigens and produce cytokines that elicit appropriate types of …

CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ

N Negi, BK Das - International reviews of immunology, 2018 - Taylor & Francis
The cardinal dogma of central nervous system (CNS) immunology believed brain is an
immune privileged site, but scientific evidences gathered so far have overturned this notion …

Biology of the blood–nerve barrier and its alteration in immune mediated neuropathies

T Kanda - Journal of Neurology, Neurosurgery & Psychiatry, 2013 - jnnp.bmj.com
The blood–nerve barrier (BNB) is a dynamic and competent interface between the
endoneurial microenvironment and the surrounding extracellular space or blood. It is …

Molecular anti-inflammatory mechanisms of retinoids and carotenoids in Alzheimer's disease: A review of current evidence

N Mohammadzadeh Honarvar… - Journal of Molecular …, 2017 - Springer
Alzheimer's disease (AD) is considered as one of the most prevalent neurodegenerative
disorders characterized by progressive loss of mental function and ability to learn. AD is a …