High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress [S]

LK Townsend, KD Medak, WT Peppler, GM Meers… - Journal of Lipid …, 2019 - ASBMB
The relationship between liver interleukin-6 (IL-6) resistance following high-fat diet (HFD)-
induced obesity and glucose intolerance is unclear. The purpose of this study was to assess …

Subcutaneous inguinal white adipose tissue is responsive to, but dispensable for, the metabolic health benefits of exercise

WT Peppler, LK Townsend, CM Knuth… - American Journal …, 2018 - journals.physiology.org
Exercise training has robust effects on subcutaneous inguinal white adipose tissue (iWAT),
characterized by a shift to a brown adipose tissue (BAT)-like phenotype. Consistent with this …

Long-term, high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration

V Politis-Barber, HS Brunetta… - American Journal …, 2020 - journals.physiology.org
White adipose tissue (WAT) dysfunction in obesity is implicated in the onset of whole body
insulin resistance. Alterations in mitochondrial bioenergetics, namely impaired mitochondrial …

Voluntary wheel running reduces weight gain in mice by decreasing high-fat food consumption

J Cordeira, D Monahan - Physiology & behavior, 2019 - Elsevier
We investigated whether wheel running for just 30 min on 5 days each week, an exercise
routine based on recommended levels of physical activity for adults, regulates body weight …

GLP1 receptor agonism protects against acute olanzapine-induced hyperglycemia

KD Medak, H Shamshoum… - American Journal of …, 2020 - journals.physiology.org
Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of
schizophrenia and a number of off-label conditions. Although effective in reducing …

The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued by cilostamide

KD Medak, GL McKie, H Shamshoum… - Physiological …, 2022 - Wiley Online Library
Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243
(CL) results in remodeling of white adipose tissue (WAT) characterized by increased …

Glucagon receptor knockout mice are protected against acute olanzapine-induced hyperglycemia

LN Castellani, WT Peppler, CD Sutton… - …, 2017 - Elsevier
Objectives To determine if glucagon is involved in mediating the increase in blood glucose
levels caused by the second-generation antipsychotic drug olanzapine. Materials and …

Female mice are protected against acute olanzapine-induced hyperglycemia

KD Medak, LK Townsend, MK Hahn… - Psychoneuroendocrinology, 2019 - Elsevier
Olanzapine is a second-generation antipsychotic (SGA) used frequently in the treatment of
schizophrenia and a growing list of off-label conditions. Though effective in reducing …

Distinct gut microbiota and serum metabolites in response to weight loss induced by either dairy or exercise in a rodent model of obesity

S Mayengbam, B Mickiewicz, SK Trottier… - Journal of proteome …, 2019 - ACS Publications
Energy imbalance is a primary cause of obesity. While the classical approach to attenuate
weight gain includes an increase in energy expenditure through exercise, dietary …

Exercise and dairy protein have distinct effects on indices of liver and systemic lipid metabolism

LK Townsend, S Gandhi, H Shamshoum, SK Trottier… - …, 2020 - Wiley Online Library
Objective This study aimed to explore the individual and combined effects of skim milk
powder (SMP) and exercise on indices of systemic and liver lipid metabolism in male obese …