Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system
that often leads to disability in young adults. Treatment options are limited and often only …

Regulatory T cells (Tregs) are key mediators of immune tolerance and feature prominently in
cancer. Depletion of CD25+ FoxP3+ Tregs in vivo may promote T cell cancer …

Natural killer (NK) cells are important innate effectors in immunity. NK cells also have a role
in the regulation of the adaptive immune response, and have been shown, in different …

Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological
disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of …

Background Daclizumab, a humanised monoclonal antibody, modulates interleukin-2
signalling by blocking the α subunit (CD25) of the interleukin-2 receptor. We assessed …

Although Foxp3+ regulatory T cells (Tregs) require interleukin-2 (IL-2) for their development,
it has been unclear whether continuing IL-2 signals are needed to maintain lineage stability …

Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous
clinical presentations and course. MS is considered to be a T cell mediated disease but in …

Rapamycin/interleukin-2 (IL-2) combination treatment of NOD mice effectively treats
autoimmune diabetes. We performed a phase 1 clinical trial to test the safety and …

Regulation of T cell responses by innate lymphoid cells (ILCs) is increasingly documented
and studied. Direct or indirect crosstalk between ILCs and T cells early during and after T …