Mucosal-associated invariant T (MAIT) cells are innate T cells expressing an invariant Vα7. 2-
Jα33 T-cell antigen receptor α chain and are enriched in mucosal-associated lymphoid …

Recent studies suggested that human CD56 bright CD16− NK cells may play a role in the
regulation of the immune response. Since the mechanism (s) involved have not yet been …

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous
system (CNS) in which demyelination and neurodegeneration occurs. The immune system …

The treatment landscape for relapsing forms of multiple sclerosis (RMS) has expanded
considerably over the last 10 years with the approval of multiple new disease-modifying …

Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense
against viruses. Through their cytolytic capacity and generation of cytokines and …

Objective Inaccessibility of the inflammation compartmentalized to the central nervous
system (CNS) may underlie the lack of efficacy of immunomodulatory treatments in …

Adaptive immunity has traditionally been considered a unique feature of vertebrate
physiology. Unlike innate immune responses, which remain essentially unchanged upon …

Natural killer (NK) cells are important mediators of the immune response against microbial
pathogens and tumors. There is growing evidence from mouse and human studies that, NK …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
characterised by widespread areas of focal demyelination. Its aetiology and pathogenesis …

Abstract Background Mesenchymal stromal cells (MSCs) and their extracellular vesicles
(MSC-EVs) have demonstrated to elicit immunomodulatory and pro-regenerative properties …