Pathophysiology of type 2 diabetes mellitus
U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …
The physical frailty syndrome as a transition from homeostatic symphony to cacophony
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …
Association between insulin resistance and the development of cardiovascular disease
V Ormazabal, S Nair, O Elfeky, C Aguayo… - Cardiovascular …, 2018 - Springer
For many years, cardiovascular disease (CVD) has been the leading cause of death around
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …
Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity
G Jia, MA Hill, JR Sowers - Circulation research, 2018 - Am Heart Assoc
Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …
Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling
Y Wu, M Chen, J Jiang - Mitochondrion, 2019 - Elsevier
Mitochondrial dysfunction is becoming one of the most emerging pathological process in the
etiology of neurological disorders. Other common etiologies of the neurological disorders …
etiology of neurological disorders. Other common etiologies of the neurological disorders …
Cellular senescence drives age-dependent hepatic steatosis
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular
senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of …
senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of …
[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …
Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy
M Tong, T Saito, P Zhai, S Oka, W Mizushima… - Circulation …, 2019 - Am Heart Assoc
Rationale: Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic
dysfunction, and intracellular lipid accumulation, termed lipotoxicity. Diabetic hearts utilize …
dysfunction, and intracellular lipid accumulation, termed lipotoxicity. Diabetic hearts utilize …
Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue
SC da Silva Rosa, N Nayak, AM Caymo… - Physiological …, 2020 - Wiley Online Library
Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
G Jia, VG DeMarco, JR Sowers - Nature Reviews Endocrinology, 2016 - nature.com
Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote
the development of a specific form of cardiomyopathy that is independent of coronary artery …
the development of a specific form of cardiomyopathy that is independent of coronary artery …