PBPK models for the prediction of in vivo performance of oral dosage forms

ES Kostewicz, L Aarons, M Bergstrand… - European Journal of …, 2014 - Elsevier
Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

The intestinal microbiota and obesity

SJ Kallus, LJ Brandt - Journal of clinical gastroenterology, 2012 - journals.lww.com
Obesity has been and continues to be an epidemic in the United States. Obesity has been
addressed in multiple health initiatives, including Healthy People 2010, with no state …

Small intestinal bacterial overgrowth in patients with irritable bowel syndrome

I Posserud, PO Stotzer, ES Björnsson, H Abrahamsson… - Gut, 2007 - gut.bmj.com
Background: Small intestinal bacterial overgrowth (SIBO) has been proposed to be common
in irritable bowel syndrome (IBS), with altered small-bowel motility as a possible …

Interactions between commensal bacteria and gut sensorimotor function in health and disease

G Barbara, V Stanghellini, G Brandi… - Official journal of the …, 2005 - journals.lww.com
Commensal bacteria inhabiting the human intestine (ie, intestinal microflora) participate in
the development and maintenance of gut sensory and motor functions, including the …

Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats

E Husebye, PM Hellström, F Sundler… - American Journal …, 2001 - journals.physiology.org
The effect of an intestinal microflora consisting of selected microbial species on myoelectric
activity of small intestine was studied using germ-free rat models, with recording before and …

[HTML][HTML] Short bowel syndrome as the leading cause of intestinal failure in early life: some insights into the management

O Goulet, E Abi Nader, B Pigneur… - … , hepatology & nutrition, 2019 - synapse.koreamed.org
Intestinal failure (IF) is the critical reduction of the gut mass or its function below the minimum
needed to absorb nutrients and fluids required for adequate growth in children. Severe IF …

Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth

C Jacobs, E Coss Adame, A Attaluri… - Alimentary …, 2013 - Wiley Online Library
Background Whether intestinal dysmotility and the use of a proton pump inhibitor (PPI) either
independently or together contributes to small intestinal bacterial overgrowth (SIBO), and/or …

[PDF][PDF] Neurohumoral control of gastrointestinal motility

MB Hansen - Physiological research, 2003 - Citeseer
Neurohumoral substances and their receptors play a major part in the complex regulation of
gastrointestinal motility and have therefore been the predominant targets for drug …

Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: a prospective randomized trial

GA Woodard, B Encarnacion, JR Downey… - Journal of …, 2009 - Elsevier
Introduction Roux-en-Y gastric bypass (RNYGB) surgery offers an effective and enduring
treatment for morbid obesity. Gastric bypass may alter gastrointestinal (GI) flora possibly …

[HTML][HTML] Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system

J Worsøe, L Fynne, T Gregersen, V Schlageter… - BMC …, 2011 - Springer
Background Tracking an ingested magnet by the Magnet Tracking System MTS-1 (Motilis,
Lausanne, Switzerland) is an easy and minimally-invasive method to assess gastrointestinal …