The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …

Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an
important therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage the IN dimer …

Retroviral integrases catalyze two reactions, 3′-processing of viral DNA ends, followed by
integration of the processed ends into chromosomal DNA. X-ray crystal structures of …

Integration of viral DNA into cellular DNA is an essential step in the replication cycle of HIV
and other retroviruses. The first antiviral drugs that target integrase, the viral enzyme that …

Antiretroviral inhibitors that are used to manage HIV infection/AIDS predominantly target
three enzymes required for virus replication: reverse transcriptase, protease, and integrase …

Retroviruses are the only animal viruses that require the stable integration of genetic
information into the genome of the host cell as an obligate step in replication. All members of …

Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations,
referred to as class II substitutions, exhibit pleiotropic effects during virus replication …

Integration of a desossiribonucleic acid (DNA) copy of the viral ribonucleic acid (RNA) into
host genomes is a fundamental step in the replication cycle of all retroviruses. The highly …