One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that
include the methionine and folate cycles that are central to cellular function, providing 1C …

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

Abstract S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on
central nervous system function through cellular transmethylation pathways, including the …

Recent investigations have revealed that changes in DNA methylation status play an
important role in aging-associated pathologies and lifespan. The methylation of DNA is …

Dynamic metabolism is exhibited by early mammalian embryos to support changing cell
fates during development. It is widely acknowledged that metabolic pathways not only satisfy …

Oviductal extracellular vesicles (oEVs) have been proposed as key modulators of
gamete/embryo maternal interactions. The aim of this study was to examine the metabolite …

Medically assisted reproductive technologies, such as in vitro embryo production, are
increasingly being used to palliate infertility. Eggs are produced following a hormonal …

Polyamines (PAs) are important molecules that determine cell longevity or death. Studies
have shown that nutritional supplementation with spermidine can reduce age-related …

Choline is a precursor of acetylcholine, phosphatidylcholine, and the methyl-donor betaine.
Reports indicate that supplementation with rumen-protected choline improves postpartum …

In this review, we discuss the functions and main effects on pregnancy outcomes of three
agents that have the ability to induce epigenetic modifications: valproic acid (VPA), a well …