In silico repositioning of approved drugs for rare and neglected diseases
One approach to speed up drug discovery is to examine new uses for existing approved
drugs, so-called 'drug repositioning'or 'drug repurposing', which has become increasingly …
drugs, so-called 'drug repositioning'or 'drug repurposing', which has become increasingly …
Potential repurposed drug candidates for tuberculosis treatment: progress and update of drugs identified in over a decade
The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades.
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …
Doxycycline host-directed therapy in human pulmonary tuberculosis
QH Miow, AF Vallejo, Y Wang, JM Hong… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Matrix metalloproteinases (MMPs) are key regulators of tissue destruction in
tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II …
tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II …
Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases
Rationale: Tuberculosis kills more than 1.5 million people per year, and standard treatment
has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix …
has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix …
Synthesis, structure–activity relationship of novel substituted 4H-chromen-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer …
Abstract Series of 4H-chromen-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives 7a–
7zb, 8a–8d and 9a–9d were synthesized and screened for their in vitro anti-mycobacterial …
7zb, 8a–8d and 9a–9d were synthesized and screened for their in vitro anti-mycobacterial …
Antibacterial activity of long-chain fatty alcohols against mycobacteria
K Mukherjee, P Tribedi… - FEMS microbiology …, 2013 - academic.oup.com
Tuberculosis is caused by the bacterium Mycobacterium tuberculosis and results in
innumerable deaths across the world. The emergence of multidrug-resistant and extremely …
innumerable deaths across the world. The emergence of multidrug-resistant and extremely …
Antimicrobial peptides as an alternative to anti-tuberculosis drugs
Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite
the introduction four decades ago of the affordable and efficient four-drugs (isoniazid …
the introduction four decades ago of the affordable and efficient four-drugs (isoniazid …
Looking beyond typical treatments for atypical mycobacteria
CM Bento, MS Gomes, T Silva - Antibiotics, 2020 - mdpi.com
The genus Mycobacterium comprises not only the deadliest of bacterial pathogens,
Mycobacterium tuberculosis, but several other pathogenic species, including M. avium and …
Mycobacterium tuberculosis, but several other pathogenic species, including M. avium and …
[HTML][HTML] Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis
Tuberculosis (TB) remains a serious concern more than two decades on from when the
World Health Organization declared it a global health emergency. The alarming rise of …
World Health Organization declared it a global health emergency. The alarming rise of …
Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxybenzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold
M Krátký, J Vinšová, M Volková, V Buchta… - European journal of …, 2012 - Elsevier
A series of novel sulfonamides containing 5-chloro-2-hydroxybenzaldehyde or 5-chloro-2-
hydroxybenzoic acid scaffolds were designed, synthesized and characterized by IR, 1H …
hydroxybenzoic acid scaffolds were designed, synthesized and characterized by IR, 1H …