Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Abstract Introduction Recently, Nrf2/HO-1 has received extensive attention as the main
regulatory pathway of intracellular defense against oxidative stress and is considered an …

Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Rationale: Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and
features of plaque instability, in part, through lipid-mediated oxidative DNA damage and …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Lipid accumulation in podocytes is a major determinant of diabetic kidney disease (DKD)
and identification of potential therapeutic targets by mediating podocyte lipid metabolism …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Background Atherosclerosis (AS) is the basis of diabetic macrovascular complications. The
plasma low-density lipoprotein (LDL) particles transcytosis across endothelial cells (ECs) …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Over decades of studies, accumulating evidence has suggested that epigenetic
dysregulation is a hallmark of tumours. Post-translational modifications of histones are …