Hereditary prostate cancer: genes related, target therapy and prevention

MT Vietri, G D'Elia, G Caliendo, M Resse… - International journal of …, 2021 - mdpi.com
Prostate cancer (PCa) is globally the second most diagnosed cancer type and the most
common cause of cancer-related deaths in men. Family history of PCa, hereditary breast …

Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions

R Kucera, L Pecen, O Topolcan, AR Dahal… - EPMA Journal, 2020 - Springer
In the early twenty-first century, societies around the world are facing the paradoxal
epidemic development of PCa as a non-communicable disease. PCa is the most frequently …

[HTML][HTML] Family history of prostate cancer and survival outcomes in the UK genetic prostate cancer study

MN Brook, HN Raghallaigh, K Govindasami, T Dadaev… - European Urology, 2023 - Elsevier
Background A family history (FH) of prostate cancer (PrCa) is associated with an increased
likelihood of PrCa diagnosis. Conflicting evidence exists regarding familial PrCa and clinical …

Systemic effects reflected in specific biomarker patterns are instrumental for the paradigm change in prostate cancer management: a strategic paper

O Golubnitschaja, P Kubatka, A Mazurakova, M Samec… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer (PCa) incidence is increasing globally. The costs of
treating PCa are currently increasing more rapidly than those of any other cancer, due to an …

Hereditary prostate cancer–Primetime for genetic testing?

I Heidegger, I Tsaur, H Borgmann, C Surcel… - Cancer treatment …, 2019 - Elsevier
Prostate cancer (PCa) remains the most common cancer in men. The proportion of all PCa
attributable to high-risk hereditary factors has been estimated to 5–15%. Recent landmark …

Mutational spectrum of DNA damage and mismatch repair genes in prostate cancer

FC Bugoye, R Torrorey-Sawe, R Biegon… - Frontiers in …, 2023 - frontiersin.org
Over the past few years, a number of studies have revealed that a significant number of men
with prostate cancer had genetic defects in the DNA damage repair gene response and …

Increased Risk of Hereditary Prostate Cancer in Italian Families with Hereditary Breast and Ovarian Cancer Syndrome Harboring Mutations in BRCA and in Other …

G D'Elia, G Caliendo, MM Tzioni, L Albanese… - Genes, 2022 - mdpi.com
Hereditary prostate cancer (HPCa) has the highest heritability of any cancer in men.
Interestingly, it occurs in several hereditary syndromes, including breast and ovarian cancer …

Impact of family history on oncological outcomes in primary therapy for localized prostate cancer patients: a systematic review and meta-analysis

F Urabe, S Kimura, S Yamamoto, K Tashiro… - Prostate Cancer and …, 2021 - nature.com
Background The influence of family history on oncological outcomes of prostate cancer
remains controversial. We conducted a systematic literature review and meta-analysis to …

Recent Research Advances in Double-Strand Break and Mismatch Repair Defects in Prostate Cancer and Potential Clinical Applications

D Jaworski, B Brzoszczyk, Ł Szylberg - Cells, 2023 - mdpi.com
Prostate cancer remains a leading cause of cancer-related death in men worldwide. Recent
research advances have emphasized the critical roles of mismatch repair (MMR) and double …

Impact of family history on clinicopathological variables and disease progression in Japanese prostate cancer patients undergoing robotic‐assisted radical …

T Sasaki, R Matsumoto, S Higashi… - … Journal of Urology, 2022 - Wiley Online Library
Objective We evaluated whether a first‐degree family history (FH) of prostate cancer (PCa)
in Japanese patients undergoing robotic‐assisted radical prostatectomy (RP) is correlated …