Clathrin-mediated endocytosis is initiated by a network of weakly interacting proteins
through a poorly understood mechanism. Ede1, the yeast homolog of mammalian Eps15, is …

The correct execution of many cellular processes, such as division and motility, requires the
cell to adopt a specific shape. Physically, these shapes are determined by the interplay of …

Even the simplest cells show a remarkable degree of intracellular patterning. Like
developing multicellular organisms, single cells break symmetry to establish polarity axes …

Cells self-organize using reaction-diffusion and fluid-flow principles. Whether bulk
membrane flows contribute to cell patterning has not been established. Here, using …

Attachment of ubiquitin (Ub) to cell surface proteins serves as a signal for internalization via
clathrin-mediated endocytosis (CME). How ubiquitinated membrane proteins engage the …

Forces generated by actin assembly assist membrane invagination during clathrin-mediated
endocytosis (CME). The sequential recruitment of core endocytic proteins and regulatory …

Membrane vesiculation is an energy-costing process. Previous studies paid much attention
to proteins with curvature-inducing motifs. Recent publications reveal that the liquid-like …

Background Myo1e is a nonmuscle motor protein enriched in podocytes. Mutations in
MYO1E are associated with steroid-resistant nephrotic syndrome (SRNS). Most of the …

Proteins that drive processes like clathrin-mediated endocytosis (CME) are expressed at
copy numbers within a cell and across cell types varying from hundreds (eg auxilin) to …

Forces generated by actin assembly assist membrane invagination during clathrin-mediated
endocytosis (CME). The sequential recruitment of core endocytic proteins and regulatory …