Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

Connexin43 (Cx43) is commonly associated with direct cell–cell communication through
gap junctions (GJs). However, recent groundbreaking studies have challenged this dogma …

The accumulation of senescent cells is a key characteristic of aging, leading to the
progression of age-related diseases such as osteoarthritis (OA). Previous data from our …

Oxidative stress is a major risk factor that causes osteocyte cell death and bone loss. Prior
studies primarily focus on the function of cell surface expressed Cx43 channels. Here, we …

The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of
proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte …

Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an
overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with …

Classically associated with gap junction-mediated intercellular communication, connexin43
(Cx43) is increasingly recognized to possess non-canonical biological functions, including …

Connexons form the basis of hemichannels and gap junctions. They are composed of six
tetraspan proteins called connexins. Connexons can function as individual hemichannels …

The exquisite cartilage architecture maintains an orderly dynamic equilibrium as a result of
the interplay between chondrocyte functions and the unique extracellular matrix (ECM) …

Articular cartilage consists of hyaline cartilage, is a major constituent of the human
musculoskeletal system and has critical functions in frictionless joint movement and articular …