Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

Bone is a dynamic tissue that is constantly renewed. The cell populations that participate in
this process—the osteoblasts and osteoclasts—are derived from different progenitor pools …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

Despite nearly two decades passing since the discovery of gene fusions involving TFE3 or
TFEB in sporadic renal cell carcinoma (RCC), the molecular mechanisms underlying the …

NFATc1 has been characterized as a master regulator of nuclear factor κB ligand-induced
osteoclast differentiation. Herein, we demonstrate a novel role for NFATc1 as a positive …

Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …

The receptor activator of NF-κB ligand (RANKL) induces various osteoclast-specific marker
genes during osteoclast differentiation mediated by mitogen-activated protein (MAP) kinase …

IL-1 is a potent cytokine that can induce bone erosion in inflammatory sites such as
rheumatoid joint regions via activation of osteoclasts. Not only is IL-1 capable of activating …

Recently a close relationship between the immune and skeletal systems or the
interdisciplinary field called osteoimmunology has attracted much attention due to the …

The strength and integrity of the human skeleton depends on a delicate equilibrium between
bone resorption by osteoclasts and bone formation by osteoblasts. This equilibrium is …