Immune dysregulation in autism spectrum disorder: what do we know about it?
MA Robinson-Agramonte, E Noris García… - International journal of …, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental
disorders characterized by a wide and variable set of neuropsychiatric symptoms, including …
disorders characterized by a wide and variable set of neuropsychiatric symptoms, including …
Immune mediators in the brain and peripheral tissues in autism spectrum disorder
ML Estes, AK McAllister - Nature Reviews Neuroscience, 2015 - nature.com
Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …
disorder (ASD). Several ASD risk genes encode components of the immune system and …
Ultrastructure of synapses in the mammalian brain
KM Harris, RJ Weinberg - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
The morphology and molecular composition of synapses provide the structural basis for
synaptic function. This article reviews the electron microscopy of excitatory synapses on …
synaptic function. This article reviews the electron microscopy of excitatory synapses on …
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
C Cebrián, FA Zucca, P Mauri, JA Steinbeck… - Nature …, 2014 - nature.com
Subsets of rodent neurons are reported to express major histocompatibility complex class I
(MHC-I), but such expression has not been reported in normal adult human neurons. Here …
(MHC-I), but such expression has not been reported in normal adult human neurons. Here …
[HTML][HTML] Synapse elimination and learning rules co-regulated by MHC class I H2-Db
The formation of precise connections between retina and lateral geniculate nucleus (LGN)
involves the activity-dependent elimination of some synapses, with strengthening and …
involves the activity-dependent elimination of some synapses, with strengthening and …
MHCI negatively regulates synapse density during the establishment of cortical connections
MW Glynn, BM Elmer, PA Garay, XB Liu… - Nature …, 2011 - nature.com
Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent
refinement and plasticity. We found that MHCI also negatively regulates the density and …
refinement and plasticity. We found that MHCI also negatively regulates the density and …
Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis
SW Song, CJ Miranda, L Braun, K Meyer, AE Frakes… - Nature medicine, 2016 - nature.com
Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic to
motor neurons (MNs) and play a non–cell autonomous role in disease pathogenesis. The …
motor neurons (MNs) and play a non–cell autonomous role in disease pathogenesis. The …
Major histocompatibility complex class I proteins in brain development and plasticity
BM Elmer, AK McAllister - Trends in neurosciences, 2012 - cell.com
Proper development of the central nervous system (CNS) requires the establishment of
appropriate connections between neurons. Recent work suggests that this process is …
appropriate connections between neurons. Recent work suggests that this process is …
Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
[HTML][HTML] The major histocompatibility complex (MHC) in schizophrenia: a review
R Mokhtari, HM Lachman - Journal of clinical & cellular …, 2016 - ncbi.nlm.nih.gov
Epidemiological studies and mouse models suggest that maternal immune activation,
induced clinically through prenatal exposure to one of several infectious diseases, is a risk …
induced clinically through prenatal exposure to one of several infectious diseases, is a risk …