Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental
disorders characterized by a wide and variable set of neuropsychiatric symptoms, including …

Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

The morphology and molecular composition of synapses provide the structural basis for
synaptic function. This article reviews the electron microscopy of excitatory synapses on …

Subsets of rodent neurons are reported to express major histocompatibility complex class I
(MHC-I), but such expression has not been reported in normal adult human neurons. Here …

The formation of precise connections between retina and lateral geniculate nucleus (LGN)
involves the activity-dependent elimination of some synapses, with strengthening and …

Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent
refinement and plasticity. We found that MHCI also negatively regulates the density and …

Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic to
motor neurons (MNs) and play a non–cell autonomous role in disease pathogenesis. The …

Proper development of the central nervous system (CNS) requires the establishment of
appropriate connections between neurons. Recent work suggests that this process is …

Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

Epidemiological studies and mouse models suggest that maternal immune activation,
induced clinically through prenatal exposure to one of several infectious diseases, is a risk …