Lipoprotein (a) metabolism: potential sites for therapeutic targets

J Hoover-Plow, M Huang - Metabolism, 2013 - Elsevier
Lipoprotein (a)[Lp (a)] resembles low-density lipoprotein (LDL), with an LDL lipid core and
apolipoprotein B (apoB), but contains a unique apolipoprotein, apo (a). Elevated Lp (a) is an …

[HTML][HTML] Lipoprotein (a): a promising marker for residual cardiovascular risk assessment

A Cai, L Li, Y Zhang, Y Mo, W Mai, Y Zhou - Disease markers, 2013 - hindawi.com
Atherosclerotic cardiovascular diseases (CVD) are still the leading cause of morbidity and
mortality worldwide, although optimal medical therapy has been prescribed for primary and …

[HTML][HTML] Lipoprotein (a) and its role in inflammation, atherosclerosis and malignancies

E Orsó, G Schmitz - Clinical research in cardiology supplements, 2017 - Springer
Abstract Lipoprotein (a)(Lp (a)) is a modified low-density lipoprotein (LDL) particle with an
additional specific apolipoprotein (a), covalently attached to apolipoprotein B‑100 of LDL by …

[HTML][HTML] Investigation of a nonsense mutation located in the complex KIV-2 copy number variation region of apolipoprotein (a) in 10,910 individuals

S Di Maio, R Grüneis, G Streiter, C Lamina… - Genome medicine, 2020 - Springer
Background The concentrations of the highly atherogenic lipoprotein (a)[Lp (a)] are mainly
genetically determined by the LPA gene locus. However, up to 70% of the coding sequence …

[HTML][HTML] Lipoprotein (a) hyperlipidemia as cardiovascular risk factor: pathophysiological aspects

G Schmitz, E Orsó - Clinical research in cardiology supplements, 2015 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a modified LDL particle with an additional apolipoprotein
[apo (a)] protein covalently attached by a thioester bond. Multiple isoforms of apo (a) exist …

Lipoprotein (a): genotype–phenotype relationship and impact on atherogenic risk

B Enkhmaa, E Anuurad, W Zhang, T Tran… - … syndrome and related …, 2011 - liebertpub.com
In 2010, more than 45 years after the initial discovery of lipoprotein (a)[Lp (a)] by Kare Berg,
an European Atherosclerosis Society Consensus Panel recommended screening for …

[HTML][HTML] The kringle IV type 2 domain variant 4925G> A causes the elusive association signal of the LPA pentanucleotide repeat

R Grüneis, H Weissensteiner, C Lamina… - Journal of Lipid …, 2022 - ASBMB
Abstract Lipoprotein (a)[Lp (a)] concentrations are regulated by the LPA gene mainly via the
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …

Lipoprotein (a): A Case for Universal Screening in Youth

A Alankar, PC Brar, B Kohn - Current Atherosclerosis Reports, 2023 - Springer
Abstract Purpose of Review Lipoprotein (a) has emerged as a strong independent risk factor
for cardiovascular disease. Targeted screening recommendations for Lp (a) measurement …

Increased risk of coronary artery calcification progression in subjects with high baseline Lp (a) levels: The Kangbuk Samsung Health Study

JH Cho, ES Lee, J Kim, SE Park, CY Park… - International Journal of …, 2016 - Elsevier
Background Results from previous studies support the association of lipoprotein (a)[Lp (a)]
levels and coronary artery disease risk. In this study, we analyzed the association between …

Familial hypercholesterolemia and lipoprotein (a) hyperlipidemia as independent and combined cardiovascular risk factors

E Orsó, N Ahrens, G Schmitz - Atherosclerosis Supplements, 2009 - Elsevier
The phenotypic diversity of familial hypercholesterolemia (FH) and lipoprotein (a)
hyperlipidemia (Lp (a)-HLP), as defined risks for coronary artery disease with genetic …