Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology
SJ Kaar, S Natesan, R Mccutcheon, OD Howes - Neuropharmacology, 2020 - Elsevier
Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …
disorders but are ineffective for some patients and associated with side-effects and …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
RA McCutcheon, JH Krystal, OD Howes - World Psychiatry, 2020 - Wiley Online Library
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
Glutamate hypothesis in schizophrenia
Y Uno, JT Coyle - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, developing more effective therapeutic interventions is …
individual's life and on society. Thus, developing more effective therapeutic interventions is …
Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
JH Krystal, AP Kaye, S Jefferson… - Proceedings of the …, 2023 - National Acad Sciences
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
Association of ketamine with psychiatric symptoms and implications for its therapeutic use and for understanding schizophrenia: a systematic review and meta …
Importance Ketamine hydrochloride is increasingly used to treat depression and other
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …
Structural insights into the inhibition of glycine reuptake
A Shahsavar, P Stohler, G Bourenkov, I Zimmermann… - Nature, 2021 - nature.com
The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation
and inhibition through the sodium-and chloride-dependent reuptake of glycine,–. Inhibition …
and inhibition through the sodium-and chloride-dependent reuptake of glycine,–. Inhibition …
Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia
H Rosenbrock, M Desch, G Wunderlich - European archives of psychiatry …, 2023 - Springer
Schizophrenia is a psychiatric disorder characterised by symptoms in three domains:
positive (eg delusions, hallucinations), negative (eg social withdrawal, lack of motivation) …
positive (eg delusions, hallucinations), negative (eg social withdrawal, lack of motivation) …
The druggability of solute carriers
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …
function, including growth, metabolism, and communication. Protein transporters are the …