Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

Highlights•Quercetin significantly ameliorated the phenotypes and decreased the ROS
production levels in DPN rats.•Quercetin was firstly found to modulate gut microbiota in DPN …

Neuroinflammation is associated with the pathogenesis of many neurological disorders
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …

Sirtuin (SIRT1) inactivation underlies the pathogenesis of insulin resistance and
hyperglycaemia-associated vascular complications, but its role in diabetic neuropathy (DN) …

Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes
mellitus (DM) and affects over one-third of all patients. Neuropathic pain and nerve …

Morin, a bioflavonoid with diverse pharmacological effects against various diseases; in most
cases morin protective effects were attributed to its detoxifying effect against reactive oxygen …

High glucose levels in the peripheral nervous system (PNS) have been implicated in the
pathogenesis of diabetic neuropathy (DN). However, our understanding of the molecular …

Background Diabetic peripheral neuropathy (DPN) is the most common complication of type
2 diabetes (T2D). Although the cellular and molecular mechanisms of DPN are poorly …

Impaired adenosine monophosphate kinase (AMPK) signalling under hyperglycaemic
conditions is known to cause mitochondrial dysfunction in diabetic sensory neurons …