Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

To combat hostile viruses, bacteria and archaea have evolved a unique antiviral defense
system composed of clustered regularly interspaced short palindromic repeats (CRISPRs) …

The persistence of latently infected cells in patients under combinatory antiretroviral therapy
(cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are …

The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …

Quantifying the replication-competent HIV reservoir is essential for evaluating curative
strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to …

The HIV latent reservoir represents the major challenge to cure development. Residing in
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …

Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …

ABSTRACT HIV infection treatment strategies have historically defined effectiveness through
measuring patient plasma HIV RNA. While combined antiretroviral therapy (cART) can …

Acquired immunodeficiency syndrome (AIDS) has become one of the most devastating
pandemics in recorded history. The main causal agent of AIDS is the human …