Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

Brain malignancies can either originate from within the CNS (gliomas) or invade from other
locations in the body (metastases). A highly immunosuppressive tumor microenvironment …

Inflammation is central to pathogenic processes in diabetes mellitus and the metabolic
syndrome and particularly implicates innate immunity in the development of complications …

Anosmia is one of the most prevalent symptoms of SARS-CoV-2 infection during the COVID-
19 pandemic. However, the cellular mechanism behind the sudden loss of smell has not yet …

The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …

Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge
downwards to the bulb. Both passive and active IP mechanisms protect HFs from …

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …