Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …

Background CIS43LS is a monoclonal antibody that was shown to protect against controlled
Plasmodium falciparum infection in a phase 1 clinical trial. Whether a monoclonal antibody …

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …

Background Cabamiquine is a novel antimalarial that inhibits Plasmodium falciparum
translation elongation factor 2. We investigated the causal chemoprophylactic activity and …

Fluorescence and light microscopy are important tools in the history of natural science.
However, the resolution of microscopes is limited by the diffraction of light. One possible …

Abstract Background Artesunate–amodiaquine (AS–AQ) and artemether–lumefantrine (AL)
are the currently recommended first-and second-line therapies for uncomplicated …

Background The effectiveness of community delivery of intermittent preventive treatment (C-
IPT) of malaria in pregnancy (IPTp) with sulfadoxine–pyrimethamine has been evaluated in …

Schistosomiasis treatment entirely relies on a single drug, praziquantel, prompting research
into alternative therapeutics. Here we evaluated the efficacy and safety of the antimalarial …

Background Seasonal malaria chemoprevention (SMC) is recommended for disease control
in settings with moderate to high Plasmodium falciparum transmission and currently …