[HTML][HTML] Insulin resistance is cheerfully hitched with hypertension

S Sinha, M Haque - Life, 2022 - mdpi.com
Cardiovascular diseases and type 2 diabetes mellitus (T2DM) have risen steadily
worldwide, particularly in low-income and developing countries. In the last hundred years …

miRNA delivery for skin wound healing

Z Meng, D Zhou, Y Gao, M Zeng, W Wang - Advanced drug delivery reviews, 2018 - Elsevier
The wound healing has remained a worldwide challenge as one of significant public health
problems. Pathological scars and chronic wounds caused by injury, aging or diabetes lead …

Melatonin therapy for diabetic cardiomyopathy: a mechanism involving Syk-mitochondrial complex I-SERCA pathway

H Zhou, Y Yue, J Wang, Q Ma, Y Chen - Cellular signalling, 2018 - Elsevier
Melatonin and its metabolites have been demonstrated to modulate the glucose,
dyslipidemia and other metabolic disorders. This study aimed to explore a novel mechanism …

Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway

Y Liu, J Zhao, X Mu, J Deng, X Wu, W He, Y Liu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Centella asiatica (L.) Urban is an ethnobotanical herb. The
main bioactive components of Centella asiatica are pentacyclic triterpenoid glycosides …

MicroRNA-615-5p regulates angiogenesis and tissue repair by targeting AKT/eNOS (protein kinase B/endothelial nitric oxide synthase) signaling in endothelial cells

B Icli, W Wu, D Ozdemir, H Li, HS Cheng… - … and Vascular Biology, 2019 - Am Heart Assoc
Objective—In response to tissue injury, the appropriate progression of events in
angiogenesis is controlled by a careful balance between pro and antiangiogenic factors. We …

Antimicrobial peptides: the promising therapeutics for cutaneous wound healing

F Miao, Y Li, Z Tai, Y Zhang, Y Gao… - Macromolecular …, 2021 - Wiley Online Library
Chronic wound infections have caused an increasing number of deaths and economic
burden, which necessitates wound treatment options. Hitherto, the development of functional …

The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis

Q Feng, S Zheng, J Zheng - Bioscience reports, 2018 - portlandpress.com
Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and
environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet …

The clinical potential of adipogenesis and obesity-related microRNAs

M Zaiou, H El Amri, A Bakillah - Nutrition, Metabolism and Cardiovascular …, 2018 - Elsevier
Obesity is a growing health problem commonly associated with numerous metabolic
disorders including type 2 diabetes, hypertension, cardiovascular disease, and some forms …

[HTML][HTML] DNA hypermethylation and differential gene expression associated with Klinefelter syndrome

A Skakkebæk, MM Nielsen, C Trolle, S Vang… - Scientific Reports, 2018 - nature.com
Klinefelter syndrome (KS) has a prevalence ranging from 85 to 250 per 100.000 newborn
boys making it the most frequent sex chromosome aneuploidy in the general population …

MicroRNAs and their delivery in diabetic fibrosis

A Wonnacott, L Denby, RJM Coward, DJ Fraser… - Advanced drug delivery …, 2022 - Elsevier
The global prevalence of diabetes mellitus was estimated to be 463 million people in 2019
and is predicted to rise to 700 million by 2045. The associated financial and societal costs of …