[HTML][HTML] MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression

J Liu, J Wang, W Fu, X Wang, H Chen, X Wu… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Diabetic foot ulcers are recalcitrant to healing, and poor angiogenesis is considered as the
main contributing factor. We aimed to explore the effect of extracellular vesicles (EVs) …

Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy

D Xu, X Zhang, X Chen, S Yang, H Chen - Life sciences, 2020 - Elsevier
Diabetic cardiomyopathy (DCM) is an independent and specific cardiomyopathy, which is
associated with cardiac failure in diabetic patients. Currently, the pathogenesis of DCM is a …

Insights into the diagnostic potential of extracellular vesicles and their miRNA signature from liquid biopsy as early biomarkers of diabetic micro/macrovascular …

V La Marca, A Fierabracci - International journal of molecular sciences, 2017 - mdpi.com
Extracellular vesicles (EVs) represent a heterogeneous population of small vesicles,
consisting of a phospholipidic bilayer surrounding a soluble interior cargo. Almost all cell …

Therapeutic strategies in the development of anti-viral drugs and vaccines against SARS-CoV-2 infection

JS Bhatti, GK Bhatti, N Khullar, AP Reddy… - Molecular …, 2020 - Springer
The whole world is currently facing a pandemic of an infectious disease known as novel
coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome …

Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing

Z Piperigkou, M Götte, AD Theocharis… - Advanced drug delivery …, 2018 - Elsevier
Extracellular matrix (ECM) is a dynamic network of macromolecules, playing a regulatory
role in cell functions, tissue regeneration and remodeling. Wound healing is a tissue repair …

A novel transthyretin/STAT4/miR-223-3p/FBXW7 signaling pathway affects neovascularization in diabetic retinopathy

J Shao, G Fan, X Yin, Y Gu, X Wang, Y Xin… - Molecular and cellular …, 2019 - Elsevier
MicroRNAs (miRNAs) are small RNAs without protein-coding functions that negatively
regulate target genes and play important roles in physiological and pathological processes …

Therapeutic potential of miRNAs for type 2 diabetes mellitus: an overview

P Palihaderu, B Mendis, J Premarathne… - Epigenetics …, 2022 - journals.sagepub.com
MicroRNA (miRNA) s have been identified as an emerging class for therapeutic
interventions mainly due to their extracellularly stable presence in humans and animals and …

Role of microRNAs in pressure ulcer immune response, pathogenesis, and treatment

SM Niemiec, AE Louiselle, KW Liechty… - International journal of …, 2020 - mdpi.com
Pressure ulcers are preventable, yet highly prevalent, chronic wounds that have significant
patient morbidity and high healthcare costs. Like other chronic wounds, they are …

MicroRNA 21 emerging role in diabetic complications: a critical update

D Roy, A Modi, M Khokhar… - Current diabetes …, 2021 - ingentaconnect.com
Background: Diabetes Mellitus is a multifactorial disease encompassing various pathogenic
pathways. To avoid morbidity and mortality related to diabetic complications, early detection …

MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS

F Barutta, B Corbetta, S Bellini, S Guarrera… - Journal of translational …, 2021 - Springer
Abstract Background MicroRNA-146a-5p (miR-146a-5p) is a key regulator of inflammatory
processes. Expression of miR-146a-5p is altered in target organs of diabetic complications …