Network analysis of atherosclerotic genes elucidates druggable targets

SK Banik, S Baishya, A Das Talukdar… - BMC medical …, 2022 - Springer
Background Atherosclerosis is one of the major causes of cardiovascular disease. It is
characterized by the accumulation of atherosclerotic plaque in arteries under the influence …

[HTML][HTML] Diabetes mellitus and prevalence of other comorbid conditions: a systematic review

H Bodke, V Wagh, G Kakar - Cureus, 2023 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood
glucose levels, severity continues to rise worldwide. This systematic review seeks to …

[HTML][HTML] Insight into miRNAs related with glucometabolic disorder

B Zhang, C Shen, B Zhu, H An, B Zheng, S Xu… - Biomedicine & …, 2019 - Elsevier
A microRNA (miRNA) is a single-stranded, small and non-coding RNA molecule that
contains 20–25 nucleotides. More than 2000 miRNAs have been identified in human genes …

miR-942-5p promotes the proliferation and invasion of human melanoma cells by targeting DKK3

W Zhang, K Mao, S Liu, Y Xu, J Ren - Journal of Receptors and …, 2021 - Taylor & Francis
Objective The purpose of this study was to figure out the dysregulation of miR-942-5p in
melanoma and its role in melanoma pathogenesis. Methods Quantitative real-time PCR …

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

R Cao, H Tian, Y Zhang, G Liu, H Xu, G Rao… - MedComm, 2023 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic
disorders worldwide and is a strong contributor for a broad range of comorbidities, including …

Systematic analysis of circRNA biomarkers for diagnosis, prognosis and therapy in colorectal cancer

Y Xiao, M Qiu, C Tan, W Huang, S Hu, X Jiang… - Frontiers in …, 2022 - frontiersin.org
As the third most common cancer and the second leading cause of cancer death worldwide,
colorectal cancer (CRC) poses a serious threat to people's health. In recent years, circRNA …

Down-regulation of SIRT1 expression by mir-23b contributes to lipid accumulation in HepG2 cells

M Borji, M Nourbakhsh, SM Shafiee, AA Owji… - Biochemical …, 2019 - Springer
Non-alcoholic fatty liver disease is one of the main causes of chronic liver disease and
therefore is currently considered a major public health problem. Sirtuin 1 (SIRT1) is an NAD …

Redox signaling in diabetic retinopathy and opportunity for therapeutic intervention through natural products

M Wang, KJ Sheng, JC Fang, H Zhao, SM Lu… - European Journal of …, 2022 - Elsevier
Diabetic retinopathy (DR) is a common serious complication of diabetes that accounts for the
leading cause of blindness among the working-age population in developed countries …

[HTML][HTML] Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through the mammalian target of rapamycin (mTOR) signaling pathway

YB Kandemir, V Tosun… - Advances in Clinical and …, 2019 - advances.umw.edu.pl
Background. Several studies demonstrated that the overexpression of mammalian target of
rapamycin (mTOR) signaling protein is associated with cardiomyopathy. However, the effect …

[HTML][HTML] miR-503/Apelin-12 mediates high glucose-induced microvascular endothelial cells injury via JNK and p38MAPK signaling pathway

K Chen, XL Zhao, LB Li, LY Huang, Z Tang, J Luo… - Regenerative …, 2020 - Elsevier
Introduction Diabetic patients are often accompanied by complications of diabetic vascular
disease, which could lead to heart failure or stroke. In this work, we explored the role of miR …