Vitamin B12, folate, and the methionine remethylation cycle—biochemistry, pathways, and regulation
DS Froese, B Fowler… - Journal of inherited …, 2019 - Wiley Online Library
Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …
Diverse bacterial microcompartment organelles
C Chowdhury, S Sinha, S Chun… - Microbiology and …, 2014 - Am Soc Microbiol
Bacterial microcompartments (MCPs) are sophisticated protein-based organelles used to
optimize metabolic pathways. They consist of metabolic enzymes encapsulated within a …
optimize metabolic pathways. They consist of metabolic enzymes encapsulated within a …
Navigating the B12 road: assimilation, delivery, and disorders of cobalamin
C Gherasim, M Lofgren, R Banerjee - Journal of Biological Chemistry, 2013 - ASBMB
The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility,
supporting both methyl transfer and isomerization reactions. During evolution of higher …
supporting both methyl transfer and isomerization reactions. During evolution of higher …
The tinker, tailor, soldier in intracellular B12 trafficking
The recognition of eight discrete genetic complementation groups among patients with
inherited cobalamin disorders provided early insights into the complexity of a cofactor …
inherited cobalamin disorders provided early insights into the complexity of a cofactor …
Genetic disorders of vitamin B12 metabolism: eight complementation groups–eight genes
DS Froese, RA Gravel - Expert reviews in molecular medicine, 2010 - cambridge.org
Vitamin B12 (cobalamin, Cbl) is an essential nutrient in human metabolism. Genetic
diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn …
diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn …
[HTML][HTML] Isolated methylmalonic acidemia
I Manoli, JL Sloan, CP Venditti - 2016 - europepmc.org
For this GeneReview, the term" isolated methylmalonic acidemia" refers to a group of inborn
errors of metabolism associated with elevated methylmalonic acid (MMA) concentration in …
errors of metabolism associated with elevated methylmalonic acid (MMA) concentration in …
B12 Trafficking in Mammals: A Case for Coenzyme Escort Service
R Banerjee - ACS chemical biology, 2006 - ACS Publications
Many coenzymes are vitamins that are assimilated in mammals into their active form from
precursors obtained from the diet. They are often both rare and reactive rendering the …
precursors obtained from the diet. They are often both rare and reactive rendering the …
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
Vitamin B 12 (cobalamin, Cbl) is essential to the function of two human enzymes, methionine
synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its …
synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its …
Conversion of cobinamide into adenosylcobamide in bacteria and archaea
JC Escalante-Semerena - Journal of bacteriology, 2007 - Am Soc Microbiol
Adenosylcobalamin (AdoCbl, also known as [aka] coenzyme B12) is the most complex
coenzyme known, and its biosynthesis requires a great deal of genetic information (Fig …
coenzyme known, and its biosynthesis requires a great deal of genetic information (Fig …