Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Bacterial microcompartments (MCPs) are sophisticated protein-based organelles used to
optimize metabolic pathways. They consist of metabolic enzymes encapsulated within a …

The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility,
supporting both methyl transfer and isomerization reactions. During evolution of higher …

The recognition of eight discrete genetic complementation groups among patients with
inherited cobalamin disorders provided early insights into the complexity of a cofactor …

Vitamin B12 (cobalamin, Cbl) is an essential nutrient in human metabolism. Genetic
diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn …

Cobalamin (Cbl), also known as vitamin B12, is an indispensable water-soluble molecule.
As far as it is known at present, its function is restricted to cofactorial activity for only two …

For this GeneReview, the term" isolated methylmalonic acidemia" refers to a group of inborn
errors of metabolism associated with elevated methylmalonic acid (MMA) concentration in …

Many coenzymes are vitamins that are assimilated in mammals into their active form from
precursors obtained from the diet. They are often both rare and reactive rendering the …

Vitamin B 12 (cobalamin, Cbl) is essential to the function of two human enzymes, methionine
synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its …

Adenosylcobalamin (AdoCbl, also known as [aka] coenzyme B12) is the most complex
coenzyme known, and its biosynthesis requires a great deal of genetic information (Fig …