Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Acylation of biomolecules (eg, proteins and small molecules) is a process that occurs in cells
of all domains of life and has emerged as a critical mechanism for the control of many …

Lysine acetylation is a frequently occurring posttranslational modification in bacteria;
however, little is known about its origin and regulation. Using the model bacterium …

The emerging view of Nε-lysine acetylation in eukaryotes is of a relatively abundant post-
translational modification (PTM) that has a major impact on the function, structure, stability …

ABSTRACT N ε-Lysine acetylation is now recognized as an abundant posttranslational
modification (PTM) that influences many essential biological pathways. Advancements in …

Although protein acetylation is widely observed, it has been associated with few specific
regulatory functions making it poorly understood. To interrogate its functionality, we …

Two-component regulatory systems represent the major paradigm for signal transduction in
prokaryotes. The simplest systems are composed of a sensor kinase and a response …

Posttranslational modification of a protein, either alone or in combination with other
modifications, can control properties of that protein, such as enzymatic activity, localization …

Lysine residues can be post-translationally modified by various acyl modifications in
bacteria and eukarya. Here, we showed that two major acyl modifications, acetylation and …

The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates
virulence in response to various signals for bacteria within the mammalian host. Here, we …