A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances, optimization techniques, and applications

HI Shahin, L Chablani - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug
delivery. However, designing DPIs with adequate physicochemical properties is …

Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs

S Radivojev, S Zellnitz, A Paudel, E Froehlich - International journal of …, 2019 - Elsevier
Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

[HTML][HTML] In vitro dissolution and permeability testing of inhalation products: Challenges and advances

A Nokhodchi, S Chavan, T Ghafourian - Pharmaceutics, 2023 - mdpi.com
In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …

[HTML][HTML] Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal …

R Kaur, SR Dennison, AJ Burrow… - Journal of …, 2021 - Springer
Background Incidence of pulmonary aspergillosis is rising worldwide, owing to an increased
population of immunocompromised patients. Notable potential of the pulmonary route has …

Co-electrospraying technology as a novel approach for dry powder inhalation formulation of montelukast and budesonide for pulmonary co-delivery

S Yaqoubi, K Adibkia, A Nokhodchi, S Emami… - International Journal of …, 2020 - Elsevier
In the current study electrospraying methodology was used for particle engineering of
montelukast and budesonide to prepare a combined inhalable dry powder formulation …

[HTML][HTML] RespiCellTM: An Innovative Dissolution Apparatus for Inhaled Products

F Sonvico, V Chierici, G Varacca, E Quarta, D D'angelo… - Pharmaceutics, 2021 - mdpi.com
To overcome some of the shortfalls of the types of dissolution testing currently used for
pulmonary products, a new custom-built dissolution apparatus has been developed. For …

[HTML][HTML] Sodium hyaluronate nanocomposite respirable microparticles to tackle antibiotic resistance with potential application in treatment of mycobacterial pulmonary …

I Rossi, F Buttini, F Sonvico, F Affaticati, F Martinelli… - Pharmaceutics, 2019 - mdpi.com
Tuberculosis resistant cases have been estimated to grow every year. Besides
Mycobacterium tuberculosis, other mycobacterial species are responsible for an increasing …

Production of fast-dissolving low-density powders for improved lung deposition by spray drying of a nanosuspension

K Šimková, B Joost, G Imanidis - European Journal of Pharmaceutics and …, 2020 - Elsevier
We combined high-energy wet media milling and spray drying to engineer dry powders for
inhalation consisting of geometrically large, low-density particles with superior aerodynamic …

Effect of magnesium stearate surface coating method on the aerosol performance and permeability of micronized fluticasone propionate

V Kumar, B Sethi, E Yanez, DH Leung… - International journal of …, 2022 - Elsevier
In this study, we evaluated the aerodynamic performance, dissolution, and permeation
behavior of micronized fluticasone propionate (FP) and magnesium stearate (MgSt) binary …

Anti-inflammatory flurbiprofen nasal powders for nose-to-brain delivery in Alzheimer's disease

L Tiozzo Fasiolo, MD Manniello, F Bortolotti… - Journal of Drug …, 2019 - Taylor & Francis
Neuroinflammation occurs in the early stages of Alzheimer's disease (AD). Thus, anti-
inflammatory drugs in this asymptomatic initial phase could slow down AD progression …