A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances, optimization techniques, and applications
HI Shahin, L Chablani - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug
delivery. However, designing DPIs with adequate physicochemical properties is …
delivery. However, designing DPIs with adequate physicochemical properties is …
Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs
S Radivojev, S Zellnitz, A Paudel, E Froehlich - International journal of …, 2019 - Elsevier
Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …
formulations for systemic treatment have been developed. For efficient development of …
[HTML][HTML] In vitro dissolution and permeability testing of inhalation products: Challenges and advances
A Nokhodchi, S Chavan, T Ghafourian - Pharmaceutics, 2023 - mdpi.com
In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …
inhalation drug products. Although the regulatory bodies have specific guidelines for the …
[HTML][HTML] Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal …
R Kaur, SR Dennison, AJ Burrow… - Journal of …, 2021 - Springer
Background Incidence of pulmonary aspergillosis is rising worldwide, owing to an increased
population of immunocompromised patients. Notable potential of the pulmonary route has …
population of immunocompromised patients. Notable potential of the pulmonary route has …
Co-electrospraying technology as a novel approach for dry powder inhalation formulation of montelukast and budesonide for pulmonary co-delivery
In the current study electrospraying methodology was used for particle engineering of
montelukast and budesonide to prepare a combined inhalable dry powder formulation …
montelukast and budesonide to prepare a combined inhalable dry powder formulation …
[HTML][HTML] RespiCellTM: An Innovative Dissolution Apparatus for Inhaled Products
F Sonvico, V Chierici, G Varacca, E Quarta, D D'angelo… - Pharmaceutics, 2021 - mdpi.com
To overcome some of the shortfalls of the types of dissolution testing currently used for
pulmonary products, a new custom-built dissolution apparatus has been developed. For …
pulmonary products, a new custom-built dissolution apparatus has been developed. For …
[HTML][HTML] Sodium hyaluronate nanocomposite respirable microparticles to tackle antibiotic resistance with potential application in treatment of mycobacterial pulmonary …
I Rossi, F Buttini, F Sonvico, F Affaticati, F Martinelli… - Pharmaceutics, 2019 - mdpi.com
Tuberculosis resistant cases have been estimated to grow every year. Besides
Mycobacterium tuberculosis, other mycobacterial species are responsible for an increasing …
Mycobacterium tuberculosis, other mycobacterial species are responsible for an increasing …
Production of fast-dissolving low-density powders for improved lung deposition by spray drying of a nanosuspension
K Šimková, B Joost, G Imanidis - European Journal of Pharmaceutics and …, 2020 - Elsevier
We combined high-energy wet media milling and spray drying to engineer dry powders for
inhalation consisting of geometrically large, low-density particles with superior aerodynamic …
inhalation consisting of geometrically large, low-density particles with superior aerodynamic …
Effect of magnesium stearate surface coating method on the aerosol performance and permeability of micronized fluticasone propionate
In this study, we evaluated the aerodynamic performance, dissolution, and permeation
behavior of micronized fluticasone propionate (FP) and magnesium stearate (MgSt) binary …
behavior of micronized fluticasone propionate (FP) and magnesium stearate (MgSt) binary …
Anti-inflammatory flurbiprofen nasal powders for nose-to-brain delivery in Alzheimer's disease
L Tiozzo Fasiolo, MD Manniello, F Bortolotti… - Journal of Drug …, 2019 - Taylor & Francis
Neuroinflammation occurs in the early stages of Alzheimer's disease (AD). Thus, anti-
inflammatory drugs in this asymptomatic initial phase could slow down AD progression …
inflammatory drugs in this asymptomatic initial phase could slow down AD progression …