Food components and dietary habits: keys for a healthy gut microbiota composition
The gut microbiota is a changing ecosystem, containing trillions of bacteria, continuously
shaped by many factors, such as dietary habits, seasonality, lifestyle, stress, antibiotics use …
shaped by many factors, such as dietary habits, seasonality, lifestyle, stress, antibiotics use …
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases
M Zu, Y Ma, B Cannup, D Xie, Y Jung, J Zhang… - Advanced Drug Delivery …, 2021 - Elsevier
The incidence of inflammatory bowel disease (IBD) is rapidly rising throughout the world.
Although tremendous efforts have been made, limited therapeutics are available for IBD …
Although tremendous efforts have been made, limited therapeutics are available for IBD …
Bioorthogonal PROTAC prodrugs enabled by on-target activation
Although proteolysis targeting chimeras (PROTACs) have become promising therapeutic
modalities, important concerns exist about the potential toxicity of the approach owing to …
modalities, important concerns exist about the potential toxicity of the approach owing to …
Effector T helper cell subsets in inflammatory bowel diseases
The gastrointestinal tract is a site of high immune challenge, as it must maintain a delicate
balance between tolerating luminal contents and generating an immune response toward …
balance between tolerating luminal contents and generating an immune response toward …
[HTML][HTML] Gut immune maturation depends on colonization with a host-specific microbiota
Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We
colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to …
colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to …
Selective in vivo metabolic cell-labeling-mediated cancer targeting
Distinguishing cancer cells from normal cells through surface receptors is vital for cancer
diagnosis and targeted therapy. Metabolic glycoengineering of unnatural sugars provides a …
diagnosis and targeted therapy. Metabolic glycoengineering of unnatural sugars provides a …
Intestinal intraepithelial lymphocytes: sentinels of the mucosal barrier
D Olivares-Villagómez, L Van Kaer - Trends in immunology, 2018 - cell.com
Intestinal intraepithelial lymphocytes (IELs) are a large and diverse population of lymphoid
cells that reside between the intestinal epithelial cells (IECs) that form the intestinal mucosal …
cells that reside between the intestinal epithelial cells (IECs) that form the intestinal mucosal …
Revisiting inflammatory bowel disease: pathology, treatments, challenges and emerging therapeutics including drug leads from natural products
Inflammatory bowel disease (IBD) is a chronic and life-long disease characterized by
gastrointestinal tract inflammation. It is caused by the interplay of the host's genetic …
gastrointestinal tract inflammation. It is caused by the interplay of the host's genetic …
Points of control in inflammation
C Nathan - Nature, 2002 - nature.com
Inflammation is a complex set of interactions among soluble factors and cells that can arise
in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimmune injury …
in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimmune injury …
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
YY Kong, H Yoshida, I Sarosi, HL Tan, E Timms… - Nature, 1999 - nature.com
The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as
TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation …
TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation …