Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …

Alzheimer's disease (AD) is one of the fastest growing cognitive decline-related neurological
diseases. To date, effective curative strategies have remained elusive. A growing body of …

Macroautophagy/autophagy is a highly regulated process involved in the turnover of
cytosolic components, however its pivotal role in maintenance of bone homeostasis remains …

Alzheimer's disease (AD) is the most common neurodegenerative disease. Pathological
proteins of AD mainly contain amyloid-beta (Aβ) and tau. Their deposition will lead to neuron …

Millions of protein molecules are synthesized per minute in each cell, and simultaneously,
millions of protein molecules are degraded. Mutated and misfolded newly synthesized …

Autophagy is a lysosome-dependent intracellular degradation process that allows recycling
of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of …