[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Defining the role of natural killer cells in COVID-19
Natural killer (NK) cells are critical effectors of antiviral immunity. Researchers have
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …
[HTML][HTML] Oral antiviral treatments for COVID-19: opportunities and challenges
L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …
and prevent disease progression to a more severe form. However, the timing of antiviral …
[HTML][HTML] SARS-CoV-2 non-structural proteins and their roles in host immune evasion
Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …
continues to threaten public health. The etiological agent of this devastating pandemic …
[HTML][HTML] Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …
infection has become a global pandemic due to the high viral transmissibility and …
Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
[HTML][HTML] SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D
Natural killer (NK) cells are cytotoxic effector cells that target and lyse virally infected cells;
many viruses therefore encode mechanisms to escape such NK cell killing. Here, we …
many viruses therefore encode mechanisms to escape such NK cell killing. Here, we …
[HTML][HTML] Characterization of SARS-CoV-2 evasion: interferon pathway and therapeutic options
M Znaidia, C Demeret, S van der Werf, AV Komarova - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to …
current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to …
[HTML][HTML] Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses
All betacoronaviruses (β-CoVs) encode non-structural protein 1 (Nsp1), an essential
pathogenicity factor that potently restricts host gene expression. Among the β-CoV family …
pathogenicity factor that potently restricts host gene expression. Among the β-CoV family …
Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
A Borsatto, O Akkad, I Galdadas, S Ma, S Damfo… - Elife, 2022 - elifesciences.org
Non-structural protein 1 (Nsp1) is a main pathogenicity factor of α-and β-coronaviruses.
Nsp1 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suppresses the …
Nsp1 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suppresses the …