Many bacterial and archaeal organisms use clustered regularly interspaced short
palindromic repeats–CRISPR associated (CRISPR–Cas) systems to defend themselves …

Prokaryotes have developed numerous defense strategies to combat the constant threat
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …

The principal biological function of bacterial and archaeal CRISPR systems is RNA-guided
adaptive immunity against viruses and other mobile genetic elements (MGEs). These …

CRISPR–Cas systems of bacteria and archaea comprise chromosomal loci with typical
repetitive clusters and associated genes encoding a range of Cas proteins. Adaptation of …

CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that
protects against viral infection by targeting specific invading nucleic acid sequences …

Cyclic oligonucleotide-based antiphage signaling system (CBASS) immunity is a
widespread form of antiphage defense in bacteria and archaea. Each CBASS operon …

Advances in our understanding of prokaryotic antiphage defense mechanisms in the past
few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a …

Direct, amplification-free detection of RNA has the potential to transform molecular
diagnostics by enabling simple on-site analysis of human or environmental samples …

Characteristic properties of type III CRISPR-Cas systems include recognition of target RNA
and the subsequent induction of a multifaceted immune response. This involves sequence …

In the type III CRISPR–Cas immune response of prokaryotes, infection triggers the
production of cyclic oligoadenylates that bind and activate proteins that contain a CARF …