Key Clinical Points Primary Ovarian Insufficiency Primary ovarian insufficiency should be
considered in women younger than 40 years of age who present with new-onset irregular …

Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early
depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in …

Iron, as an essential trace element for the organism, is vital for maintaining the organism's
health. Excessive iron can promote reactive oxygen species (ROS) accumulation, thus …

Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced
maternal age correlates with the progressive loss of both the quantity and quality of oocytes …

Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized
by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix …

The formation of functional eggs (oocyte) in ovarian follicles is arguably one of the most
important events in early mammalian development since the oocytes provide the bulk …

STUDY QUESTION Is it possible to find the cause of primary ovarian insufficiency (POI) in
more women by extensive screening? SUMMARY ANSWER Adding next generation …

Egg weight (EW) and age at first egg (AFE) are economically important traits in breeder
chicken production. The genetic basis of these traits, however, is far from understood …

Background Ovarian folliculogenesis is a tightly regulated process leading to the formation
of functional oocytes and involving successive quality control mechanisms that monitor …

Premature ovarian insufficiency (POI) is a clinically heterogeneous disease that may
seriously affect the physical and mental health of women of reproductive age. POI primarily …