[HTML][HTML] The future of pharmaceutical manufacturing sciences
J Rantanen, J Khinast - Journal of pharmaceutical sciences, 2015 - Elsevier
The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …
solutions and fundamental scientific work, enabling the production of highly engineered …
[HTML][HTML] Application of quality by design in the current drug development
L Zhang, S Mao - Asian journal of pharmaceutical sciences, 2017 - Elsevier
Quality by Test was the only way to guarantee quality of drug products before FDA launched
current Good Manufacturing Practice. To clearly understand the manufacture processes …
current Good Manufacturing Practice. To clearly understand the manufacture processes …
End‐to‐end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation
For the past decade, the pharmaceutical industry has been under pressure to improve
efficiency, as rising costs outpaced the development of new pharmaceuticals.[1] A growing …
efficiency, as rising costs outpaced the development of new pharmaceuticals.[1] A growing …
Assessment of recent process analytical technology (PAT) trends: a multiauthor review
This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …
A perspective on Quality-by-Control (QbC) in pharmaceutical continuous manufacturing
Abstract The Quality-by-Design (QbD) guidance issued by the US Food and Drug
Administration (FDA) has catalyzed the modernization of pharmaceutical manufacturing …
Administration (FDA) has catalyzed the modernization of pharmaceutical manufacturing …
Process analysis and optimization of continuous pharmaceutical manufacturing using flowsheet models
Continuous manufacturing has attracted increasing research attention in the pharmaceutical
industry within the last decade. Based on the extensive experimental studies, numerous …
industry within the last decade. Based on the extensive experimental studies, numerous …
System-wide hybrid MPC–PID control of a continuous pharmaceutical tablet manufacturing process via direct compaction
The next generation of QbD based pharmaceutical products will be manufactured through
continuous processing. This will allow the integration of online/inline monitoring tools …
continuous processing. This will allow the integration of online/inline monitoring tools …
Implementation of an advanced hybrid MPC–PID control system using PAT tools into a direct compaction continuous pharmaceutical tablet manufacturing pilot plant
It is desirable for a pharmaceutical final dosage form to be manufactured through a quality
by design (QbD)-based approach rather than a quality by testing (QbT) approach. An …
by design (QbD)-based approach rather than a quality by testing (QbT) approach. An …
A systematic framework for onsite design and implementation of a control system in a continuous tablet manufacturing process
A novel manufacturing strategy based on continuous processing integrated with
online/inline monitoring tools coupled with an advanced control system is highly desired for …
online/inline monitoring tools coupled with an advanced control system is highly desired for …
The application of an automated control strategy for an integrated continuous pharmaceutical pilot plant
Continuous manufacturing offers potential opportunities for the improved manufacturing of
pharmaceutical products. A key challenge is the development of an appropriate control …
pharmaceutical products. A key challenge is the development of an appropriate control …