Artificial chemical products are widely used and ubiquitous worldwide and pose a threat to
the environment and human health. Accumulating epidemiological and toxicological …

Background: The prenatal environment influences lifetime health; epigenetic mechanisms
likely predominate. In 2016, the first international consortium paper on cigarette smoking …

Background: Cutaneous melanoma arises from skin melanocytes and has a high risk of
metastatic spread. Despite better prevention, earlier detection, and the development of …

We are exposed to a mixture of environmental man-made and natural xenobiotics. We
experience a wide spectrum of environmental exposure in our lifetime, including the effects …

Chemical risk assessments generally focus on single substances, overlooking real-world co-
exposures to chemical mixtures. Mixture toxicology studies with representative mixtures can …

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
and represents an increasing public health issue given the limited treatment options and its …

Exposure to halogenated flame retardants (HFRs) has been associated with various
adverse effects on human health. Human exposure to HFRs mainly occurs through diet …

Marine mammals are exposed to increasing intensities of anthropogenic stressors such as
acoustic disturbance and contaminants. Correlative studies have suggested concerning …

Objective Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose
tissue, is released into circulation with weight loss, although its impact is underexplored …

Persistent organic pollutants (POPs) are toxic chemicals that can accumulate in the human
body, and particularly in adipose tissue. POPs can induce metabolic diseases via …