Melatonin is a neurohormone that is mainly secreted by the pineal gland. It coordinates the
work of the superior biological clock and consequently affects many processes in the human …

The kidney and the brain, as high-flow end organs relying on autoregulatory mechanisms,
have unique anatomic and physiological hemodynamic properties. Similarly, the two organs …

Chronic kidney disease (CKD) has become a global public health problem with high
morbidity and mortality. Renal fibrosis can lead to end-stage renal disease (ESRD) …

Methods: A comprehensive review was conducted covering a timeline from 1 January 2020
to 5 February 2022 without any restrictions. The data extraction was conducted …

The kidney is a vital organ that carries out significant metabolic functions in our body. Due to
the complexity of its role, the kidney is also susceptible to many disease conditions, such as …

Objectives: Renal diseases caused by primary hypertension (HTN) are often asymptomatic
without sensitive markers for early diagnosis and prediction, easily progressing to severe …

This study investigates the relationship and genetic mechanisms of liver and heart diseases,
focusing on the liver-heart axis (LHA) as a fundamental biological basis. Through genome …

Objectives: Renal diseases caused by primary hypertension (HTN) are often asymptomatic
without sensitive markers for early diagnosis and prediction, easily progressing to severe …

Background Chronic kidney disease (CKD) and hypertension are chronic diseases affecting
a large portion of the population frequently coexistent and interdependent. The inability to …

Hypertension is one of the major risk factors for chronic kidney disease (CKD), and the
coexistence of hypertension and CKD increases morbidity and mortality. Although many …