Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection
F Caiado, EM Pietras, MG Manz - Journal of Experimental Medicine, 2021 - rupress.org
Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …
that involves activation and consumption of immune cells in order to reestablish and …
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
JM Pickard, MY Zeng, R Caruso… - Immunological …, 2017 - Wiley Online Library
The intestinal tract of mammals is colonized by a large number of microorganisms including
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …
[HTML][HTML] BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis
E Kaufmann, J Sanz, JL Dunn, N Khan, LE Mendonça… - Cell, 2018 - cell.com
The dogma that adaptive immunity is the only arm of the immune response with memory
capacity has been recently challenged by several studies demonstrating evidence for …
capacity has been recently challenged by several studies demonstrating evidence for …
Adult haematopoietic stem cell niches
Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …
cells and regulate their function. Recent advances have improved our understanding of the …
MicroRNAs as regulatory elements in immune system logic
A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …
decisions. They act by negatively regulating the expression of key immune development …
[HTML][HTML] NOD1 and NOD2: signaling, host defense, and inflammatory disease
The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the
founding members of the intracellular NOD-like receptor family, sense conserved motifs in …
founding members of the intracellular NOD-like receptor family, sense conserved motifs in …
[HTML][HTML] Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
LV Kovtonyuk, K Fritsch, X Feng, MG Manz… - Frontiers in …, 2016 - frontiersin.org
All hematopoietic and immune cells are continuously generated by hematopoietic stem cells
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …
The ontogeny of a neutrophil: mechanisms of granulopoiesis and homeostasis
Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to
respond to inflammatory or infectious etiologies and are crucial participants in the proper …
respond to inflammatory or infectious etiologies and are crucial participants in the proper …
[HTML][HTML] Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness
Bacterial infection leads to consumption of short-lived innate immune effector cells, which
then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs …
then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs …
NOD-like receptors: versatile cytosolic sentinels
Nucleotide binding oligomerization domain (NOD)-like receptors are cytoplasmic pattern-
recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1) …
recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1) …