Targeting cell signaling in allergic asthma
SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …
Airway mucus and asthma: the role of MUC5AC and MUC5B
Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and
metaplasia result in changes in stored and secreted mucin and the production of a …
metaplasia result in changes in stored and secreted mucin and the production of a …
A cellular census of human lungs identifies novel cell states in health and in asthma
Human lungs enable efficient gas exchange and form an interface with the environment,
which depends on mucosal immunity for protection against infectious agents. Tightly …
which depends on mucosal immunity for protection against infectious agents. Tightly …
[HTML][HTML] Respiratory epithelial cells orchestrate pulmonary innate immunity
JA Whitsett, T Alenghat - Nature immunology, 2015 - nature.com
The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …
IL-4 and IL-13 signaling in allergic airway disease
N Gour, M Wills-Karp - Cytokine, 2015 - Elsevier
Aberrant production of the prototypical type 2 cytokines, interleukin (IL)-4 and IL-13 has long
been associated with the pathogenesis of allergic disorders. Despite tremendous scientific …
been associated with the pathogenesis of allergic disorders. Despite tremendous scientific …
More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
Use of fractional exhaled nitric oxide to guide the treatment of asthma: an official American Thoracic Society clinical practice guideline
SB Khatri, JM Iaccarino, A Barochia… - American journal of …, 2021 - atsjournals.org
Background: The fractional exhaled nitric oxide (FeNO) test is a point-of-care test that is
used in the assessment of asthma. Objective: To provide evidence-based clinical guidance …
used in the assessment of asthma. Objective: To provide evidence-based clinical guidance …
Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-κB pathway due to mitochondrial damage
JH Woo, HJ Seo, JY Lee, I Lee, K Jeon, B Kim… - Particle and Fibre …, 2023 - Springer
Background Polypropylene (PP) is used in various products such as disposable containers,
spoons, and automobile parts. The disposable masks used for COVID-19 prevention mainly …
spoons, and automobile parts. The disposable masks used for COVID-19 prevention mainly …
Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions
Chronic lung diseases (CLDs) are regulated by complex interactions between many
different cell types residing in lung airway tissues. Specifically, interactions between airway …
different cell types residing in lung airway tissues. Specifically, interactions between airway …
Decoding the genetic and epigenetic basis of asthma
Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …