Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

Chronic kidney disease (CKD) is a significant public health concern associated with
significant morbidity and has become one of the foremost global causes of death in recent …

Fibrosis plays an important role in the pathogenesis of long-term diabetic complications and
contributes to the development of cardiac and renal dysfunction. The aim of this …

This study was designed to investigate the controversy on the potential role of sKlotho as an
early biomarker in Chronic Kidney Disease–Mineral Bone Disorder (CKD-MBD), to assess …

Introduction: This study aimed to investigate the relationship between circulating soluble
Klotho concentration and all-cause mortality in individuals with chronic kidney disease …

Background The potential relationship between Klotho and cognitive function is limited and
controversial. This study aimed to quantify the association of Klotho and cognitive …

Background Patients with chronic kidney disease (CKD) present a higher risk of
cardiovascular (CV) morbidity and mortality compared with the general population. While …

Shortly after the discovery of Klotho, interest grew in its potential role in chronic kidney
disease (CKD). There are three isoforms of the Klotho protein: αKlotho, βKlotho and γKlotho …

Background Urine-derived stem cells (UDSCs) can be easily isolated from urine and
possess excellent stem cell characteristics, making them a promising source for cell …

Background The anti-aging protein Klotho plays a protective role in kidney disease, but its
potential as a biomarker for chronic kidney disease (CKD) is controversial. Additionally, the …