This viewpoint article on a forecast of clinically meaningful changes in the management of
systemic lupus erythematosus (SLE) in the next 10 years is based on a review of the current …

The diagnosis of nonalcoholic fatty liver disease and associated fibrosis is challenging given
the lack of signs, symptoms and nonexistent diagnostic test. Furthermore, follow up and …

Autoimmune diseases (AID) such as systemic lupus erythematosus (SLE), primary Sjögren's
syndrome (pSS), and rheumatoid arthritis (RA) are chronic inflammatory diseases in which …

Autoimmune diseases are heterogeneous pathologies characterized by a breakdown of
immunological tolerance to self, resulting in a chronic and aberrant immune response to self …

Objective EMBODY 1 (ClinicalTrials. gov identifier: NCT 01262365) and EMBODY 2
(ClinicalTrials. gov identifier: NCT 01261793) investigated the efficacy and safety of …

Despite an unprecedented rise in the number of biological therapies developed for systemic
lupus erythematosus (SLE) during the last decades, most randomised clinical trials (RCTs) …

Objective Obexelimab is an investigational, bifunctional, noncytolytic monoclonal antibody
that binds CD19 and FcyRIIb to inhibit B cells, plasmablasts, and plasma cells. This trial …

Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like
lectins. All Siglecs have at least two domains including an extracellular domain with variable …

Objectives To detail the greatest areas of unmet scientific and clinical needs in
rheumatology. Methods The 21st annual international Advances in Targeted Therapies …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by
diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ …