Purpose This review aimed to provide a complete overview of the current stance and recent
developments in antiarrhythmic neuromodulatory interventions, focusing on lifethreatening …

Abstract Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …

The genetics of PS is expanding rapidly with genes in the RAS/MAPK pathway and
transcription factors most associated with PS in humans. Brachycephalic breeds have a …

The functioning of the heart rhythm can exhibit a wide variety of dynamic behaviours under
certain conditions. In the case of rhythm disorders or cardiac arrhythmias, the natural rhythm …

Introduction: Mechanisms underlying cardiac arrhythmias are typically driven by
abnormalities in cardiac conduction and/or heterogeneities in repolarization time (RT) …

Simple Summary Animal models reflecting the human situation as accurately as possible
are still essential to develop new therapies for diseases such as heart failure. The common …

Background: An electrical storm of Torsade de Pointes arrhythmias (TdP) can be
reproducibly induced in the anesthetized chronic AV-block (CAVB) dog by infusion of the IKr …

To characterize utility of atrioventricular block (AVB) dogs as atrial fibrillation (AF) model, we
studied remodeling processes occurring in their atria in acute (< 2 weeks) and chronic (> 4 …

Background A preclinical model standardized at different remodeling stages after AV block
induction in awake state is suitable for the evaluation of improved cardiac devices. We …

Aims An automated method for determination of short-term variability (STV) of repolarization
on intracardiac electrograms (STV-ARIauto) has previously been developed for arrhythmic …