Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in
human cells. The canonical function of box C/D and box H/ACA snoRNAs is …

Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA)
pathophysiological process in the cartilage. Methods We performed RNA sequencing in 130 …

Osteoarthritis (OA) is a degenerative disease of the joints and is one of the leading causes of
disability in adults. However, there are no key therapeutics for OA and medical treatment is …

In the development of the skeleton, the long bones are arising from the process of
endochondral ossification (EO) in which cartilage is replaced by bone. This complex process …

Amyotrophic lateral sclerosis (ALS; MND, motor neuron disease) is a debilitating
neurodegenerative disease affecting 4.5 per 100,000 people per year around the world …

The knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data
continuously emerging, regarding their diverse types, applications, and roles. Particular …

Osteoarthritis (OA) is the most common type of arthritis and no longer is considered as an
absolute consequence of joint mechanical use (wear and tear); rather recent data …

Osteoarthritis presents as a change in the chondrocyte phenotype and an imbalance
between anabolic and catabolic processes. Age affects its onset and progression. Small …

Background Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a
central role in oncogenesis. Herein, we systematically evaluated expression profiles of …