Abstract Background and Aims Many inflammatory bowel disease (IBD) patients do not
respond to medical therapy. Tofacitinib is a first-in-class, partially selective inhibitor of Janus …

Background & Aims Understanding the burden of Crohn's disease (CD) and ulcerative colitis
(UC) is important for measuring treatment value. We estimated lifetime health care costs …

The IL-36 subfamily of cytokines belongs to the IL-1 superfamily and consists of three pro-
inflammatory agonists IL-36α, IL-36β, IL-36γ, and an IL-36 receptor (IL-36R) antagonist, IL …

Epidemiology, Natural History, and Risk Stratification of Crohn's Disease - Gastroenterology
Clinics Skip to Main Content Skip to Main Menu Advertisement Gastroenterology Clinics …

Background Individual diet components and specific dietary regimens have been shown to
impact the gut microbiome. Objectives Here, we explored the contribution of long-term diet …

Background Accumulating evidence implicates that gut fungi are associated with the
pathogenesis of colorectal cancer (CRC). Our previous study has revealed that Candida …

CCL11, also known as eotaxin-1, is described as an eosinophil chemoattractant, which has
been implicated in allergic and Th2 inflammatory diseases. We have reported that CCL11 is …

Human gut microbiome is a major source of human bacterial population and a significant
contribution to both positive and harmful effects. Due to its involvement in a variety of …

Background Damage to the healthy intestinal epithelial layer and regulation of the intestinal
immune system, closely interrelated, are considered pivotal parts of the curative treatment …

Precision medicine is part of five focus areas of the Challenges in IBD research document,
which also includes preclinical human IBD mechanisms, environmental triggers, novel …