Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
Muscle–organ crosstalk: the emerging roles of myokines
MCK Severinsen, BK Pedersen - Endocrine reviews, 2020 - academic.oup.com
Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …
[HTML][HTML] International exercise recommendations in older adults (ICFSR): expert consensus guidelines
The human ageing process is universal, ubiquitous and inevitable. Every physiological
function is being continuously diminished. There is a range between two distinct phenotypes …
function is being continuously diminished. There is a range between two distinct phenotypes …
[HTML][HTML] Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs
D da Luz Scheffer, A Latini - … et Biophysica Acta (BBA)-Molecular Basis of …, 2020 - Elsevier
A wide array of molecular pathways has been investigated during the past decade in order
to understand the mechanisms by which the practice of physical exercise promotes …
to understand the mechanisms by which the practice of physical exercise promotes …
Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial
Background Patients who have received mechanical ventilation can have prolonged
cognitive impairment for which there is no known treatment. We aimed to establish whether …
cognitive impairment for which there is no known treatment. We aimed to establish whether …
[HTML][HTML] Treatment options for motor and non-motor symptoms of Parkinson's disease
FC Church - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) usually presents in older adults and typically has both motor and
non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from …
non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from …
Obesity and polycystic ovary syndrome: implications for pathogenesis and novel management strategies
TM Barber, P Hanson, MO Weickert… - Clinical Medicine …, 2019 - journals.sagepub.com
Polycystic ovary syndrome (PCOS) is a common female condition typified by reproductive,
hyperandrogenic, and metabolic features. Polycystic ovary syndrome is a genetic condition …
hyperandrogenic, and metabolic features. Polycystic ovary syndrome is a genetic condition …
[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
SL McGee, M Hargreaves - Nature Reviews Endocrinology, 2020 - nature.com
Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …
diseases of modern society. It is well appreciated that regular exercise improves metabolism …
The role of exercise in the treatment of depression: biological underpinnings and clinical outcomes
RE Ross, CJ VanDerwerker, ME Saladin… - Molecular …, 2023 - nature.com
Globally, depression is a leading cause of disability and has remained so for decades.
Antidepressant medications have suboptimal outcomes and are too frequently associated …
Antidepressant medications have suboptimal outcomes and are too frequently associated …