Segmental duplications (SDs) constitute a considerable fraction of primate genomes. They
contribute to genetic variation and provide raw material for evolution. Groups of SDs are …

Advances in next-generation sequencing (NGS) technology have made personal genome
sequencing possible, and indeed, many individual human genomes have now been …

The activity and function of natural killer (NK) cells are modulated through the interactions of
multiple receptor families, of which some recognize MHC class I molecules. The high level of …

Background Recombination rates vary widely across the human genome, but little of that
variation is correlated with known DNA sequence features. The genome contains more than …

Background Osteochondromas (cartilage-capped bone tumors) are by far the most
commonly treated of all primary benign bone tumors (50%). In 15% of cases, these tumors …

The Alu family is a highly successful group of non-LTR retrotransposons ubiquitously found
in primate genomes. Similar to the L1 retrotransposon family, Alu elements integrate …

Mobile elements (MEs), making∼ 50% of primate genomes, are known to be responsible for
generating inter-and intra-species genomic variations and play important roles in genome …

The STK11/LKB1 gene encodes a ubiquitously expressed serine/threonine kinase that is
mutated in multiple sporadic cancers including non-small cell lung carcinomas, pancreatic …

Abstract Background Transposable elements (TEs) comprise~ 10% of the chicken (Gallus
gallus) genome. The content of TEs is much lower than that of mammalian genomes, where …

Submicroscopic inversions have contributed significantly to the genomic divergence
between humans and chimpanzees over evolutionary time. Those microinversions which …