Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

The interplay between excitatory and inhibitory circuits underlies the brain's processes and
their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy …

Background Neuronal hyperexcitability and inhibitory interneuron dysfunction are frequently
observed in preclinical animal models of Alzheimer's disease (AD). This study investigates …

Synapse loss is an early feature shared by many neurodegenerative diseases, and it
represents the major correlate of cognitive impairment. Recent studies reveal that microglia …

Introduction: While the prevalence of neurodegenerative diseases associated with dementia
such as Alzheimer's disease (AD) increases, our knowledge on the underlying mechanisms …

Amyloid-β (Aβ) 1-40 and 1-42 peptides are key mediators of synaptic and cognitive
dysfunction in Alzheimer's disease (AD). Whereas in AD, Aβ is found to act as a pro …

Neurodegenerative diseases are characterized by gradually progressive, selective loss of
anatomically or physiologically related neuronal systems that produce brain damage from …

Alzheimer's disease (AD) is characterized by the classical hallmarks of Aβ-deposition and
tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long …

Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …

It has been hypothesized that the brain optimizes its capacity for computation by self-
organizing to a critical point. The dynamical state of criticality is achieved by striking a …