Quinolizidine-type alkaloids: chemodiversity, occurrence, and bioactivity

W Cely-Veloza, MJ Kato, E Coy-Barrera - ACS omega, 2023 - ACS Publications
Quinolizidine alkaloids (QAs) are nitrogen-containing compounds produced naturally as
specialized metabolites distributed in plants and animals (eg, frogs, sponges). The present …

Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition

J Chen, J Liu, Y Huang, R Li, C Ma… - Drug Metabolism …, 2021 - Taylor & Francis
Herbal plants typically have complex compositions and diverse mechanisms. Among them,
bioactive constituents with relatively high exposure in vivo are likely to exhibit therapeutic …

Oxysophocarpine suppresses hepatocellular carcinoma growth and sensitizes the therapeutic blockade of anti‐Lag‐3 via reducing FGL1 expression

J Wang, W Wei, Q Tang, L Lu, Z Luo, W Li… - Cancer …, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective
treatments and ranks as the second most lethal tumor. Immunotherapy has brought great …

Gender differences in the hepatotoxicity and toxicokinetics of emodin: the potential mechanisms mediated by UGT2B7 and MRP2

L Wu, W Han, Y Chen, T Zhang, J Liu… - Molecular …, 2018 - ACS Publications
Emodin is a main anthraquinone compound which exists in Chinese traditional medicines
including Polygonum multiflorum and Rhubarb. It is documented to have obvious liver and …

Simultaneous determination of five active alkaloids from Compound Kushen Injection in rat plasma by LC–MS/MS and its application to a comparative …

S Cang, R Liu, T Wang, X Jiang, W Zhang, K Bi… - … of Chromatography B, 2019 - Elsevier
Non-small cell lung cancer (NSCLC), as the most common histological type of lung cancer
with high mortality rates, has been widely treated by Compound Kushen Injection (CKI) in …

UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro

C Hou, W Liu, Z Liang, W Han, J Li, L Ye, M Liu… - … of Pharmaceutical and …, 2018 - Elsevier
Morusin is a prenylated flavone isolated from mulberry, the branch and root bark of various
Morus species, which possesses diverse pharmacological activities. However, it lacks …

Flavokawain A inhibits cytochrome P450 in in vitro metabolic and inhibitory investigations

L Niu, L Ding, C Lu, F Zuo, K Yao, S Xu, W Li… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Flavokawain A, the major chalcone in kava extracts, was
served as beverages for informal social occasions and traditional ceremonials in most South …

[HTML][HTML] Analysis of genetic variations in CYP2C9, CYP2C19, CYP2D6 and CYP3A5 genes using oligonucleotide microarray

Y Dong, H Xiao, Q Wang, C Zhang, X Liu… - … Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
The cytochrome P450 enzymes play a critical role in the metabolism of many commonly
prescribed drugs. Among them, the most important enzymes are highly polymorphic …

Antibacterial and synergistic effects of the n-BuOH fraction of Sophora flavescens root against oral bacteria

KY Lee, SM Cha, SM Choi, JD Cha - Journal of oral science, 2017 - jstage.jst.go.jp
The antibacterial activity of an extract and several fractions of Sophora flavescens (S.
flavescens) root alone and in combination with antibiotics against oral bacteria was …

The profiling and identification of chemical components, prototypes and metabolites of Run‐zao‐zhi‐yang capsule in rat plasma, urine and bile by an UPLC‐Q‐TOF …

S Lin, X Yue, D Ouyang, Q Li… - Biomedical …, 2018 - Wiley Online Library
Abstract Run‐zao‐zhi‐yang (RZZY) capsule, a traditional Chinese medicine formula, is
popularly used for the treatment of dermatitis and eczema. However, few studies have been …