Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Extracellular vesicle-mediated bidirectional communication between heart and other organs

K Gabisonia, M Khan… - American Journal of …, 2022 - journals.physiology.org
In recent years, a wealth of studies has identified various molecular species released by
cardiac muscle under physiological and pathological conditions that exert local paracrine …

LncRNADisease v3. 0: an updated database of long non-coding RNA-associated diseases

X Lin, Y Lu, C Zhang, Q Cui, YD Tang… - Nucleic Acids …, 2024 - academic.oup.com
Systematic integration of lncRNA-disease associations is of great importance for further
understanding their underlying molecular mechanisms and exploring lncRNA-based …

Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts

T He, Q Zhang, P Xu, W Tao, F Lin, R Liu, M Li, X Duan… - Molecular Cancer, 2023 - Springer
Background The encapsulation of circular RNAs (circRNAs) into extracellular vesicles (EVs)
enables their involvement in intercellular communication and exerts an influence on the …

A Smart Nano‐Theranostic Platform Based on Dual‐microRNAs Guided Self‐Feedback Tetrahedral Entropy‐Driven DNA Circuit

S Yang, J Luo, L Zhang, L Feng, Y He, X Gao… - Advanced …, 2023 - Wiley Online Library
MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors, capable of up or down‐
regulating gene expression during tumorigenesis; they are diagnostic biomarkers or …

Circulating non-coding RNAs in chronic kidney disease and its complications

AJ van Zonneveld, Q Zhao, JI Rotmans… - Nature Reviews …, 2023 - nature.com
Post-transcriptional regulation by non-coding RNAs (ncRNAs) can modulate the expression
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …

m6A-modified circRNAs: detections, mechanisms, and prospects in cancers

S Qin, Q Zhang, Y Xu, S Ma, T Wang, Y Huang, S Ju - Molecular Medicine, 2022 - Springer
Circular RNAs (circRNAs) have become a research hotspot in recent years with their
universality, diversity, stability, conservativeness, and spatiotemporal specificity. N6 …

Systematic characterization and biological functions of non‐coding RNAs in glioblastoma

L Dai, W Liang, Z Shi, X Li, S Zhou, W Hu… - Cell …, 2023 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most malignant and aggressive type of glioma. Non‐
coding RNAs (ncRNAs) are RNAs that do not encode proteins but widely exist in eukaryotic …

Emerging functions of circular RNA in the regulation of adipocyte metabolism and obesity

Y Zhang, Z Tian, H Ye, X Sun, H Zhang, Y Sun… - Cell Death …, 2022 - nature.com
Abstract As noncoding RNAs, circular RNAs (circRNAs) are covalently enclosed
endogenous biomolecules in eukaryotes that have tissue specificity and cell specificity …

[HTML][HTML] The role of circular RNA in Diabetic Nephropathy

C Tu, L Wang, L Wei, Z Jiang - International Journal of Medical …, 2022 - ncbi.nlm.nih.gov
Diabetic nephropathy (DKD) is the most common chronic microvascular complication of
diabetes. About 20%-40% of diabetics develop DKD, which eventually leads to chronic …